ChemBridge Presents Fragment Library for Screening
 28 Apr 2010: ChemBridge’s Fragment Library is an exemplary collection of small molecules useful for fragment-based screening. The emergence and development of high throughput X-ray crystallography and NMR methodologies for drug discovery have contributed widely to the acceptance and implementation of fragment based screening. The ability to detect low affinity binders has proven invaluable in the introduction and promotion of this aspect of drug discovery and design.
ChemBridge Corporation
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Bioo Scientific Launches ELISAs for High-Throughput ApoB Quantitation
26 Apr 2010: Bioo Scientific introduces a new MaxDiscovery™ Apolipoprotein B (ApoB) ELISA Kit, a complete, two-step ELISA that analyzes the quantity of ApoB in tissues, serum, plasma or cultured cells for research purposes. This kit offers precise protein measurement along with the ability to analyze multiple samples in low-volume, high-throughput experiments.
Bioo Scientific
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Membrane Fluidity Measurements Using UV Fluorescence Polarization and the POLARstar Omega
21 Apr 2010: In this application note the POLARstar Omega microplate reader from BMG LABTECH was used to study membrane fluidity via fluorescence polarization in the UV range. The method allows for the monitoring of large scale alterations in membrane fluidity (such as phase transitions), as well as more subtle changes in lipid dynamics.
BMG LABTECH
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Sigma® Life Science Introduces World's First P53 Knockout Rat
20 Apr 2010: Sigma® Life Science introduces the world’s first p53 ‘knockout’ rat model, an important development that is expected to, due to the rat’s closer physiological and metabolic similarity to humans, significantly improve timelines for carcinogenicity screening and reduce time to market for therapeutics.
Sigma-Aldrich Corporation
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Gentronix Expands Testing Service With Micronucleus Assay
 16 Apr 2010: Gentronix introduces the Micronucleus Test (MNT) as part of the continued expansion of its in vitro genotoxicity testing services. The new service uses flow cytometric scoring and provides an additional opportunity for the early identification of compounds that are likely to exhibit genotoxic liability.
Gentronix Ltd.
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Secondary Recovery Significantly Improves Screening Quality of Fragment Libraries
14 Apr 2010: At the opening bell of the Society for Biomecular Sciences (SBS) 16th Annual Conference & Exhibition in Phoenix, Microsonic Systems Inc. (“Microsonics”) announced that its HENDRIX SM100 Ultrasonic Fluid Processor (“HENDRIX SM100”) significantly improves fragment-based drug screening quality by re-solubilizing precipitated samples back into solution.
Microsonic Systems Inc.
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Thermo Fisher Scientific Launches New Biological Assessment Cartridges
09 Apr 2010: Thermo Fisher Scientific Inc., today announced that it will introduce three new biological assessment cartridges for the Thermo Scientific Cellomics ToxInsight in vitro (IVT) toxicology platform during the annual meeting of the American Association for Cancer Research.
Thermo Scientific Pierce Protein Products
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Simplifying Peptide Bioanalysis
08 Apr 2010: This application note demonstrates that the Oasis PST μElution Method Development plate and protocol can greatly simplify extraction method development and rapidly identify an appropriate SPE sorbent and selective starting protocol for peptide bioanalysis. Such standardized approaches for determining optimal SPE recovery and concentration, and MRM-based LC/MS analysis may help to shorten time to market for peptide drugs.
Waters
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RapidFire® In Vitro ADME Applications
08 Apr 2010: This application note demonstrates the correlation between traditional LC-MS and RapidFire for a spectrum of ADME assays. The RapidFire® MS System is shown to perform in vitro ADME assays rapidly and without modifications to existing assay methods. Sample cycle times of approximately 6 seconds can also be achieved obtaining a 7 point IC50 curve in 42 seconds.
BIOCIUS Life Sciences
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Automation of Multiplexed Cell-Based Assay to Measure Induction of Gene Expression and Activity of Cytochrome P450 Isoform 3A4
08 Apr 2010: This application note demonstrates the automation of a cell-based multiplexed assay to explore how a drug can induce gene expression and inhibit activity of the same isoform, creating a useful tool to measure the stimulatory and inhibitory effects of a drug. Activity and induction of gene expression of CYP3A4 were measured using a luminogenic, cell-membrane permeable 3A4-specific substrate and a luciferin based reporter gene assay.
BioTek Instruments, Inc.
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adme-toxicology
